反应详情

To a solution of 4-bromo-6-fluoro-1H-indole-2-carbaldehyde (1.8 g, 7.4 mmol) in THF (100 mL) at r.t. was added (ethoxycarbonylmethylene)triphenylphosphorane (5 g, 14 mmol). The mixture was stirred for 2 hours at r.t. and the mixture was filtered through a silica gel pad eluted with 40% EtOAc and the filtrate was concentrated. The residue was purified by silica gel chromatography eluted with 20% EtOAc to give 1.6 g of the title compound.

1. filtrationthe mixture was filtered through a silica gel pad
2. washeluted with 40% EtOAc
3. concentrationthe filtrate was concentrated
4. customThe residue was purified by silica gel chromatography
5. washeluted with 20% EtOAc