Benzothiazole-2-carbonyl chloride → (+/-)-[9-(1,3-BENZOTHIAZOL-2-YLCARBONYL)-8-BROMO-6-FLUORO-2,3-DIHYDRO-1H-PYRROLO[1,2-a]INDOL-1-YL]ACETIC ACID

HRID 857403Notes

Reaction equation

HRID 857403 reaction equation
C[CH:2]([CH:6]1[C:10]2=[CH:11][C:12]3[C:13]([Br:19])=[CH:14][C:15]([F:18])=[CH:16][C:17]=3[N:9]2[CH2:8][CH2:7]1)[C:3]([O-:5])=[O:4].[S:20]1[C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=2[N:22]=[C:21]1[C:29](Cl)=[O:30]>>[S:20]1[C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=2[N:22]=[C:21]1[C:29]([C:11]1[C:12]2[C:13]([Br:19])=[CH:14][C:15]([F:18])=[CH:16][C:17]=2[N:9]2[CH2:8][CH2:7][CH:6]([CH2:2][C:3]([OH:5])=[O:4])[C:10]=12)=[O:30]

Participants

3

Reactant 2

HCID 2776254Benzothiazole-2-carbonyl chlorideHCID 21867442HCID 21867442, compound

Product 1

HCID 10116276(+/-)-[9-(1,3-BENZOTHIAZOL-2-YLCARBONYL)-8-BROMO-6-FLUORO-2,3-DIHYDRO-1H-PYRROLO[1,2-a]INDOL-1-YL]ACETIC ACID

Procedure

Starting from (+/−)-methyl(8-bromo-6-fluoro-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate (Example 7, Step 8) and 1,3-benzothiazole-2-carbonyl chloride, the title compound was synthesized following the procedures described in Step 1 of Example 61 and Step 10 of Example 7.

Sources & evidence

ORD record
ord-cb71c6d0cd454d7ca99d8d04b196f228
Source dataset
uspto-grants-2006_12
Patent number
US07144913B2

Reaction notes

Loading…