Quinaldoyl chloride → (+/-)-[8-BROMO-6-FLUORO-9-(QUINOLIN-2-YLCARBONYL)-2,3-DIHYDRO-1H-PYRROLO[1,2-a]INDOL-1-YL]ACETIC ACID

HRID 857405Notes

Reaction equation

HRID 857405 reaction equation
C[CH:2]([CH:6]1[C:10]2=[CH:11][C:12]3[C:13]([Br:19])=[CH:14][C:15]([F:18])=[CH:16][C:17]=3[N:9]2[CH2:8][CH2:7]1)[C:3]([O-:5])=[O:4].[N:20]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH:23]=[CH:22][C:21]=1[C:30](Cl)=[O:31]>>[Br:19][C:13]1[C:12]2[C:11]([C:30]([C:21]3[CH:22]=[CH:23][C:24]4[C:29](=[CH:28][CH:27]=[CH:26][CH:25]=4)[N:20]=3)=[O:31])=[C:10]3[CH:6]([CH2:2][C:3]([OH:5])=[O:4])[CH2:7][CH2:8][N:9]3[C:17]=2[CH:16]=[C:15]([F:18])[CH:14]=1

Participants

3

Reactant 2

HCID 2760547Quinaldoyl chlorideHCID 21867442HCID 21867442, compound

Product 1

HCID 58760727(+/-)-[8-BROMO-6-FLUORO-9-(QUINOLIN-2-YLCARBONYL)-2,3-DIHYDRO-1H-PYRROLO[1,2-a]INDOL-1-YL]ACETIC ACID

Procedure

Starting from (+/−)-methyl(8-bromo-6-fluoro-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate (Example 7, Step 8) and quinoline-2-carbonyl chloride, the title compound was synthesized following the procedures described in Step 1 of Example 61 and Step 10 of Example 7.

Sources & evidence

ORD record
ord-4d13d3293c9746d9bebf913578c45ed8
Source dataset
uspto-grants-2006_12
Patent number
US07144913B2

Reaction notes

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