HCID 90986359, compound → HCID 90963122, compound

HRID 857407Notes

Reaction equation

HRID 857407 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]2[C:18]3[C:17]([S:19]([CH3:22])(=[O:21])=[O:20])=[CH:16][C:15]([F:23])=[CH:14][C:13]=3[N:12]3[CH2:24][CH2:25][CH:26]([CH2:27][C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[C:11]=23)=[CH2:9])=[CH:4][CH:3]=1>CCO.[Pd]>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:10]2[C:18]3[C:17]([S:19]([CH3:22])(=[O:20])=[O:21])=[CH:16][C:15]([F:23])=[CH:14][C:13]=3[N:12]3[CH2:24][CH2:25][CH:26]([CH2:27][C:28]([O:30][C:31]([CH3:32])([CH3:34])[CH3:33])=[O:29])[C:11]=23)[CH3:9])=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 90986359HCID 90986359, compound

Product 1

HCID 90963122HCID 90963122, compoundYield 95.8%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of the compound of Step 3 (78 mg) and 20 mg of Pd/C (10% w/w) in EtOH (3 mL) was stirred under H2 (balloon) for 1 h. The mixture was then filtered through a silica gel pad eluted with EtOAc and the filtrate was concentrated to give 75 mg of the title compound used as such.

Workup

  1. filtrationThe mixture was then filtered through a silica gel pad
  2. washeluted with EtOAc
  3. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-67045c1e5660439bb9df273b8734a99d
Source dataset
uspto-grants-2006_12
Patent number
US07144913B2

Reaction notes

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