2-Naphthoyl chloride → [(1R)-6-FLUORO-8-ISOPROPYL-9-(2-NAPHTHOYL)-2,3-DIHYDRO-1H-PYRROLO[1,2-a]INDOL-YL]ACETIC ACID

HRID 857408Notes

Reaction equation

HRID 857408 reaction equation
C[O:2][C:3](=[O:21])[CH2:4][C@@H:5]1[C:9]2=[CH:10][C:11]3[C:12]([CH:18]([CH3:20])[CH3:19])=[CH:13][C:14]([F:17])=[CH:15][C:16]=3[N:8]2[CH2:7][CH2:6]1.[CH:22]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[CH:25]=[CH:24][C:23]=1[C:32](Cl)=[O:33]>>[F:17][C:14]1[CH:13]=[C:12]([CH:18]([CH3:19])[CH3:20])[C:11]2[C:10]([C:32]([C:23]3[CH:24]=[CH:25][C:26]4[C:31](=[CH:30][CH:29]=[CH:28][CH:27]=4)[CH:22]=3)=[O:33])=[C:9]3[C@@H:5]([CH2:4][C:3]([OH:2])=[O:21])[CH2:6][CH2:7][N:8]3[C:16]=2[CH:15]=1

Participants

3

Reactant 2

HCID 752462-Naphthoyl chlorideHCID 86594293HCID 86594293, compound

Product 1

HCID 69585189[(1R)-6-FLUORO-8-ISOPROPYL-9-(2-NAPHTHOYL)-2,3-DIHYDRO-1H-PYRROLO[1,2-a]INDOL-YL]ACETIC ACID

Procedure

Starting from methyl[(1R)-6-fluoro-8-isopropyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl]acetate (Example 44A, Step 1) and 2-naphthoyl chloride, the title compound was synthesized following the procedures described in Step 1′ of Example 61 and Step 10 of Example 7.

Sources & evidence

ORD record
ord-7150cadcb5024661bc1a5e13c2ba320b
Source dataset
uspto-grants-2006_12
Patent number
US07144913B2

Reaction notes

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