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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 857408Generated: October 31, 2026

2-Naphthoyl chloride → [(1R)-6-FLUORO-8-ISOPROPYL-9-(2-NAPHTHOYL)-2,3-DIHYDRO-1H-PYRROLO[1,2-a]INDOL-YL]ACETIC ACID

https://huagongshe.com/reaction/857408

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Naphthoyl chlorideHCID 75246—
ReactantHCID 86594293HCID 86594293—
Product[(1R)-6-FLUORO-8-ISOPROPYL-9-(2-NAPHTHOYL)-2,3-DIHYDRO-1H-PYRROLO[1,2-a]INDOL-YL]ACETIC ACIDHCID 69585189—

Reaction Steps

Starting from methyl[(1R)-6-fluoro-8-isopropyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl]acetate (Example 44A, Step 1) and 2-naphthoyl chloride, the title compound was synthesized following the procedures described in Step 1′ of Example 61 and Step 10 of Example 7.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07144913B2
Source datasetuspto-grants-2006_12
ORD IDord-7150cadcb5024661bc1a5e13c2ba320b
Source noteuspto-grants-2006_12