反应详情

Triethylammonium formate (TEAF) was prepared by adding TEA (20.0 mL) to formic acid (16.5 mL) with ice cooling. To TEAF was added benzaldehyde (3.78 mL) and 4-hydroxy-chromen-2-one (6.0 g) and the resulting mixture was heated to 130–140° C. for 3 hours, cooled to room temperature, diluted with water, and extracted with EtOAc. The organic layer was washed with brine, dried over MgSO4 and conc. in vacuo to give a light yellow solid. The crude solid was recrystallized from EtOH to give 3-Benzyl-4-hydroxy-chromen-2-one as a white solid (1.95 g).

1. temperaturethe resulting mixture was heated to 130–140° C. for 3 hours
2. extractionextracted with EtOAc
3. washThe organic layer was washed with brine
4. dry with materialdried over MgSO4 and conc. in vacuo
5. customto give a light yellow solid
6. customThe crude solid was recrystallized from EtOH