反应详情

A solution of 2-(4-Hydroxy-2-oxo-2H-chromen-3-ylmethyl)-benzoic acid in MeOH with a catalytic amount of conc. sulfuric acid was heated to reflux for 5 hours, cooled to room temperature, diluted with water and extracted with EtOAc. The organic layer was dried over MgSO4 and conc. in vacuo to give 2-(4-Hydroxy-2-oxo-2H -chromen-3-ylmethyl)-benzoic acid methyl ester as white solid. MS: 309[M−H].

1. temperatureto reflux for 5 hours
2. extractionextracted with EtOAc
3. dry with materialThe organic layer was dried over MgSO4 and conc. in vacuo