HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 2-(4-Hydroxy-2-oxo-2H-chromen-3-ylmethyl)-benzoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 2-(4-Hydroxy-2-oxo-2H-chromen-3-ylmethyl)-benzoic acid | HCID 54706448 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-(4-Hydroxy-2-oxo-2H-chromen-3-ylmethyl)-benzoic acid methyl ester | HCID 54690322 | — |
Reaction Steps
A solution of 2-(4-Hydroxy-2-oxo-2H-chromen-3-ylmethyl)-benzoic acid in MeOH with a catalytic amount of conc. sulfuric acid was heated to reflux for 5 hours, cooled to room temperature, diluted with water and extracted with EtOAc. The organic layer was dried over MgSO4 and conc. in vacuo to give 2-(4-Hydroxy-2-oxo-2H -chromen-3-ylmethyl)-benzoic acid methyl ester as white solid. MS: 309[M−H].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07145020B2 |
| Source dataset | uspto-grants-2006_12 |
| ORD ID | ord-ac56853b87e5458db4bd07a22d08c04a |
| Source note | uspto-grants-2006_12 |