Hydrochloric Acid → 2-(1h-Pyrazol-3-yl)-benzylamine hydrochloride salt

HRID 857705Notes

Reaction equation

HRID 857705 reaction equation
[ClH:1].[NH:2]1[CH:6]=[CH:5][C:4]([C:7]2[CH:21]=[CH:20][CH:19]=[CH:18][C:8]=2[CH2:9][NH:10]C(=O)OC(C)(C)C)=[N:3]1>C(OCC)(=O)C>[ClH:1].[NH:2]1[CH:6]=[CH:5][C:4]([C:7]2[CH:21]=[CH:20][CH:19]=[CH:18][C:8]=2[CH2:9][NH2:10])=[N:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178453037HCID 178453037, compound

Product 1

HCID 1784791782-(1h-Pyrazol-3-yl)-benzylamine hydrochloride salt

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Hydrogen chloride gas was bubbled through a 0° C. solution of tert-butyl 2-(1H-pyrazol-3-yl)benzylcarbamate (60 mg, 0.220 mmol) in ethyl acetate (5 ml) for 2 min and stirred for 40 min. A precipitate formed, and the suspension was concentrated in vacuo to give 2-(1H-pyrazol-3-yl)-benzylamine hydrochloride salt; MS (ES+) M+1 174.1 for C10H11N3.

Workup

  1. customA precipitate formed
  2. concentrationthe suspension was concentrated in vacuo

Sources & evidence

ORD record
ord-22a5083e6e1a44fdb08b7e75ca87b653
Source dataset
uspto-grants-2006_12
Patent number
US07144899B2

Reaction notes

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