反应详情

A mixture of 9-hydroxy-9-fluorenylcarbonyl-L-proline benzyl ester (3.8 g, 9.3 mmol) from step 1 above and 10% palladium on carbon (390 mg) in ethyl acetate (100 mL) was stirred under an atmosphere of hydrogen (balloon pressure) for 24 hours. The mixture was filtered through celite and concentrated in vacuo to give 9-hydroxy-9-fluorenylcarbonyl-L-proline. HPLC=90%, R.T.=2.97 min; M+1=324.1; 1H NMR (CD3OD, 400 MHz) δ 7.78–7.75 (m, 2H), 7.47–7.32 (m, 6H), 4.49–4.45 (q, 1H 2.42–2.30 (m, 2H), 2.01–1.94 (m, 1H), 1.78–1.71 (m, 1H), 1.58–1.41 (m, 2H).

1. filtrationThe mixture was filtered through celite and
2. concentrationconcentrated in vacuo