Hydrochloric Acid → Sodium Chloride

HRID 857756Notes

Reaction equation

HRID 857756 reaction equation
[OH:1][CH:2]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=1)[C:3]([O:5]CC)=[O:4].[OH-].[Na+:15].O.[ClH:17]>C(O)C>[OH:1][CH:2]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=1)[C:3]([OH:5])=[O:4].[Cl-:17].[Na+:15]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 962Water2×HCID 14798Sodium HydroxideHCID 21866174Ethyl 2-hydroxy-2-(2-pyridyl)acetate

Product 2

HCID 5234Sodium ChlorideHCID 4150612-Hydroxy-2-(2-pyridyl)acetic acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a stirred solution of ethyl 2-hydroxy-2-(2-pyridyl)acetate (0.5 g, 2.56 mmol) in ethanol (5 mL) was added 2.0 M NaOH in water (1.4 mL, 2.8 mmol). The resulting solution was stirred at ambient temperature for 18 h. TLC analysis indicated complete consumption of starting ester. 6.0 M HCl in water (0.46 mL, 2.8 mmol) was added and the solvents were removed under reduced pressure and the resulting solid was dried in vacuo for 18 h to give 2-hydroxy-2-(2-pyridyl)acetic acid as a mixture with sodium chloride.

Workup

  1. customconsumption of starting ester
  2. customthe solvents were removed under reduced pressure
  3. customthe resulting solid was dried in vacuo for 18 h

Sources & evidence

ORD record
ord-7c590cc2bf8f47f19eb8af2a7f8e1162
Source dataset
uspto-grants-2006_12
Patent number
US07144899B2

Reaction notes

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