Hydrochloric Acid → HCID 22385736, compound

HRID 857868Notes

Reaction equation

HRID 857868 reaction equation
[OH-].[Na+].[F:3][C:4]1[C:13]([C:14]2[C:23](=[O:24])[N:22]([CH2:25][O:26][CH2:27][CH2:28][Si:29]([CH3:32])([CH3:31])[CH3:30])[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[N:15]=2)=[CH:12][CH:11]=[CH:10][C:5]=1[C:6]([O:8]C)=[O:7].Cl>CO>[F:3][C:4]1[C:13]([C:14]2[C:23](=[O:24])[N:22]([CH2:25][O:26][CH2:27][CH2:28][Si:29]([CH3:32])([CH3:31])[CH3:30])[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[N:15]=2)=[CH:12][CH:11]=[CH:10][C:5]=1[C:6]([OH:8])=[O:7]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 22385717HCID 22385717, compound

Product 1

HCID 22385736HCID 22385736, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

5N Sodium hydroxide (0.50 ml) was added to the compound (methyl 2-fluoro-3-[3-oxo-4-(2-(trimethylsilyl)ethoxymethyl)-3,4-dihydroquinoxaline-2-yl]benzoate) (283 mg) obtained in Working Example 28-2) in methanol (2 ml). The mixture was stirred at room temperature for 2 hours. After adding the mixture to 5N hydrochloric acid, the mixture was extracted with chloroform. The organic layer was dried over magnesium sulfate, filtered, and concentrated in vacuo to give the title compound (285 mg) as a crude material, which was served in the subsequent reaction without purification.

Workup

  1. extractionthe mixture was extracted with chloroform
  2. dry with materialThe organic layer was dried over magnesium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-7807997f0b104554a355315d0aeedf39
Source dataset
uspto-grants-2006_12
Patent number
US07148224B2

Reaction notes

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