反应详情

34.0 g (261 mmol) of 2,5-bis(hydroxymethyl)tetrahydrofuran are dissolved in 260 ml of dichloromethane. A solution of 99.0 g (521 mmol) of p-toluenesulfonyl chloride in 52 ml of pyridine and 130 ml of dichloromethane is added dropwise thereto. After stirring at room temperature for 24 hours, the precipitate is filtered off with suction and washed with dichloromethane. The filtrate and the washing phases are combined, washed with dilute hydrochloric acid and then with saturated aqueous sodium bicarbonate solution, dried over magnesium sulfate and evaporated to dryness. The crude product is recrystallized from ethanol.

1. filtrationthe precipitate is filtered off with suction
2. washwashed with dichloromethane
3. washwashed with dilute hydrochloric acid
4. dry with materialwith saturated aqueous sodium bicarbonate solution, dried over magnesium sulfate
5. customevaporated to dryness
6. customThe crude product is recrystallized from ethanol