Trifluoromethanesulfonic acid → HCID 20760424, compound

HRID 857938Notes

Reaction equation

HRID 857938 reaction equation
[F:1][C:2]([F:8])([F:7])[S:3]([OH:6])(=[O:5])=[O:4].[CH2:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:11][CH:10]1[N:18]([CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][C:34]=1[F:39])[C:19]([C:21]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH:24]=[CH:23][C:22]=1O)=[O:20]>N1C=CC=CC=1>[CH2:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:11][CH:10]1[N:18]([CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][C:34]=1[F:39])[C:19]([C:21]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH:24]=[CH:23][C:22]=1[O:4][S:3]([C:2]([F:8])([F:7])[F:1])(=[O:6])=[O:5])=[O:20]

Participants

4

Reactant 2

HCID 62406Trifluoromethanesulfonic acidHCID 22567001HCID 22567001, compound

Product 1

HCID 20760424HCID 20760424, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Trifluoromethanesulfonic acid anhydrous (0.27 mL, 1.6 mmol) is added dropwise in 10 minutes to a solution of 2-hydroxy-naphthalene-1-Carboxylic acid indan-2-yl-(2-fluoro-benzyl)-amide (17) (323 mg, 0.8 mmol) in anhydrous pyridine (5 mL) at 0° C. under nitrogen. The mixture is stirred at room temperature overnight and concentrated under reduced pressure. The residue (18) is dried in vacuo and used for the next step without further purification.

Workup

  1. concentrationconcentrated under reduced pressure
  2. dry with materialThe residue (18) is dried in vacuo
  3. customused for the next step without further purification

Sources & evidence

ORD record
ord-8daffdb39bdf46388c426213f346607f
Source dataset
uspto-grants-2006_12
Patent number
US07148225B2

Reaction notes

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