Hydrochloric Acid → 2-Propylthiazolo[4,5-c]quinolin-4-amine hydrochloride

HRID 857978Notes

Reaction equation

HRID 857978 reaction equation
[CH2:1]([C:4]1[S:5][C:6]2[C:15]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[N:9]=[C:8]([NH2:16])[C:7]=2[N:17]=1)[CH2:2][CH3:3].[ClH:18]>>[ClH:18].[CH2:1]([C:4]1[S:5][C:6]2[C:15]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[N:9]=[C:8]([NH2:16])[C:7]=2[N:17]=1)[CH2:2][CH3:3]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 101987192-propylthiazolo[4,5-c]quinolin-4-amine

Product 1

HCID 226482952-Propylthiazolo[4,5-c]quinolin-4-amine hydrochloride

Procedure

Using the general method of Example 10, 2-propylthiazolo[4,5-c]quinolin-4-amine (1.75 g) was reacted with 1 equivalent of concentrated hydrochloric acid to provide 2-propylthiazolo[4,5-c]quinolin-4-amine hydrochloride as an off-white crystalline solid, m.p. 234–237° C. Analysis: Calculated for C13H13N3S HCl: % C, 55.81; % H, 5.04; % N, 15.02; Found: % C, 55.86; % H, 5.02; % N, 14.99.

Sources & evidence

ORD record
ord-3025e53bb29d40688c433fa4a3ad96bc
Source dataset
uspto-grants-2006_12
Patent number
US07148232B2

Reaction notes

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