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HRID8580

反应详情

EQUATION

反应方程式

HRID 8580 的结构方程式

REACTANTS

反应物

2
结构：NCc1ccccc1
HCID7504

Benzylamine

C7H9N

结构：Cc1ccc(S(=O)(=O)OCC2CCC(COS(=O)(=O)c3ccc(C)cc3)O2)cc1
HCID259634

(TETRAHYDROFURAN-2,5-DIYL)BIS(METHYLENE) BIS(4-METHYLBENZENESULFONATE)

C20H24O7S2

PRODUCTS

生成物

1
结构：c1ccc(CN2CC3CCC(C2)O3)cc1
HCID12069230

3-Benzyl-8-oxa-3-azabicyclo[3.2.1]octane

C13H17NO

AUXILIARIES

试剂、催化剂与溶剂

1
结构：Cc1ccccc1
溶剂HCID1140

Toluene

C7H8

PROCEDURE

实验过程

112 g (250 mmol) of 2,5-anhydro-3,4-dideoxy-1,6-bis-O-[(4-methylphenyl)sulfonyl]-hexitol from step 1 and 90.7 g (840 mmol) of benzylamine in 500 ml of toluene are heated under reflux for 20 hours. The precipitate is then filtered off with suction and washed with toluene. The combined toluene phases are concentrated in a rotary evaporator and distilled in vacuo. After a benzylamine fore-run, the product is obtained.

WORKUP

后处理

  1. temperatureunder reflux for 20 hours
  2. filtrationThe precipitate is then filtered off with suction
  3. washwashed with toluene
  4. concentrationThe combined toluene phases are concentrated in a rotary evaporator
  5. distillationdistilled in vacuo