化工社化工社 化学情報印刷レポート · 研究参考用
Benzylamine → 3-Benzyl-8-oxa-3-azabicyclo[3.2.1]octane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzylamine | HCID 7504 | — |
| 反応物 | (Tetrahydrofuran-2,5-diyl)bis(methylene) bis(4-methylbenzenesulfonate) | HCID 259634 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 3-Benzyl-8-oxa-3-azabicyclo[3.2.1]octane | HCID 12069230 | — |
反応手順
112 g (250 mmol) of 2,5-anhydro-3,4-dideoxy-1,6-bis-O-[(4-methylphenyl)sulfonyl]-hexitol from step 1 and 90.7 g (840 mmol) of benzylamine in 500 ml of toluene are heated under reflux for 20 hours. The precipitate is then filtered off with suction and washed with toluene. The combined toluene phases are concentrated in a rotary evaporator and distilled in vacuo. After a benzylamine fore-run, the product is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07091198B1 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-f28c838693d64d378a2dbf9cdb185727 |
| 出典メモ | uspto-grants-2006_08 |