反应详情

Crude {4-[(6-amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-ylcarbamoyl)-methyl]-phenyl}-carbamic acid tert-butyl ester (0.65 mmol) was added to a 4M solution of hydrogen chloride in p-dioxane (10 mL) and the mixture stirred at ambient temperature for 2 hrs. The precipitate was isolated by filtration, washed with p-dioxane and ether then dried in vacuo to give crude N-(6-amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-2-(4-amino-phenyl)-acetamide hydrochloride salt as a light beige solid which was of sufficient purity for subsequent use without additional purification (quantitative).

1. customThe precipitate was isolated by filtration
2. washwashed with p-dioxane and ether
3. customthen dried in vacuo