Hydrochloric Acid → HCID 69115132, compound

HRID 858050Notes

Reaction equation

HRID 858050 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][C:15](=[O:28])[NH:16][C:17]2[C:18](=[O:27])[N:19]([CH3:26])[C:20](=[O:25])[N:21]([CH3:24])[C:22]=2[NH2:23])=[CH:10][CH:9]=1)(C)(C)C.[ClH:30]>O1CCOCC1>[ClH:30].[NH2:23][C:22]1[N:21]([CH3:24])[C:20](=[O:25])[N:19]([CH3:26])[C:18](=[O:27])[C:17]=1[NH:16][C:15](=[O:28])[CH2:14][C:11]1[CH:10]=[CH:9][C:8]([NH2:7])=[CH:13][CH:12]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58762837HCID 58762837, compound

Product 1

HCID 69115132HCID 69115132, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Crude {4-[(6-amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-ylcarbamoyl)-methyl]-phenyl}-carbamic acid tert-butyl ester (0.65 mmol) was added to a 4M solution of hydrogen chloride in p-dioxane (10 mL) and the mixture stirred at ambient temperature for 2 hrs. The precipitate was isolated by filtration, washed with p-dioxane and ether then dried in vacuo to give crude N-(6-amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-2-(4-amino-phenyl)-acetamide hydrochloride salt as a light beige solid which was of sufficient purity for subsequent use without additional purification (quantitative).

Workup

  1. customThe precipitate was isolated by filtration
  2. washwashed with p-dioxane and ether
  3. customthen dried in vacuo

Sources & evidence

ORD record
ord-5e22bd833b1b416f9587ccf71f572006
Source dataset
uspto-grants-2006_12
Patent number
US07148229B2

Reaction notes

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