Ethylamine → 6-(Ethylamino)pyridine-3-carboxylic acid

HRID 858185Notes

Reaction equation

HRID 858185 reaction equation
Cl[C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1.[CH2:11]([NH2:13])[CH3:12]>>[CH2:11]([NH:13][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1)[CH3:12]

Participants

3

Reactant 2

HCID 6341EthylamineHCID 792226-Chloronicotinic acid

Product 1

HCID 117449946-(Ethylamino)pyridine-3-carboxylic acid

Procedure

This intermediate is prepared from 6-chloronicotinic acid and ethylamine by the same procedure as described for Example 35 step a). 1-Butanol was substituted for ethyl acetate for the extraction. Recrystallization (MeOH—CHCl3) yielded 0.53 g (50%).

Workup

  1. extraction1-Butanol was substituted for ethyl acetate for the extraction
  2. customRecrystallization (MeOH—CHCl3)
  3. customyielded 0.53 g (50%)

Sources & evidence

ORD record
ord-6697125ae1594b3486cb3b9065703dba
Source dataset
uspto-grants-2006_12
Patent number
US07148243B2

Reaction notes

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