p-Toluenesulfonic acid monohydrate → HCID 135496191, compound

HRID 858256Notes

Reaction equation

HRID 858256 reaction equation
COC1C=CC(C(O[C:10]2[C:15]([NH:16][C:17](=[O:30])[C:18]3[CH:23]=[CH:22][C:21]([O:24]C)=[C:20]([C:26]([F:29])([F:28])[F:27])[CH:19]=3)=[CH:14][C:13]([O:31]C)=[CH:12][C:11]=2[Br:33])=O)=CC=1C(F)(F)F.O.C1(C)C=CC(S(O)(=O)=O)=CC=1>>[Br:33][C:11]1[C:10]2[O:30][C:17]([C:18]3[CH:23]=[CH:22][C:21]([OH:24])=[C:20]([C:26]([F:28])([F:29])[F:27])[CH:19]=3)=[N:16][C:15]=2[CH:14]=[C:13]([OH:31])[CH:12]=1

Participants

3

Reactant 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 226691622-Bromo-4-methoxy-6-{[4-methoxy-3-(trifluoromethyl)benzoyl]amino}phenyl 4-methoxy-3-(trifluoromethyl)benzoate

Product 1

HCID 135496191HCID 135496191, compound

Procedure

The title compound was prepared in substantially the same manner as described in Example 20, Step d (Route a), from 2-bromo-4-methoxy-6-{[4-methoxy-3-(trifluoromethyl)benzoyl]amino}phenyl 4-methoxy-3-(trifluoromethyl)benzoate and p-toluenesulfonic acid monohydrate. The product was obtained as an off-white solid, m.p. 183–185° C.; MS m/e 402 (M+H)+.

Workup

  1. customThe product was obtained as an off-white solid, m.p. 183–185° C.

Sources & evidence

ORD record
ord-f53fd16c34bf437ca5b0c3a7316dd9e8
Source dataset
uspto-grants-2006_12
Patent number
US07148247B2

Reaction notes

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