反应详情

25.00 g (97.0 mmol) of 1-bromo-3-(3-methylbut-2-enylsulphonyl)benzene, 200 ml of toluene and 27.75 g (146.0 mmol) of para-toluenesulphonic acid are introduced into a three-necked flask. The reaction medium is refluxed for four hours and evaporated to dryness. The residue is taken up in aqueous sodium hydrogen carbonate solution and extracted with ethyl acetate, and the organic phase is separated out after settling has taken place, dried over magnesium sulphate and evaporated. The residue obtained is purified by chromatography on a column of silica eluted with heptane. 22.57 g (90%) of the expected compound are obtained in the form of a yellow oil.

1. temperatureThe reaction medium is refluxed for four hours
2. customevaporated to dryness
3. extractionextracted with ethyl acetate
4. customthe organic phase is separated out after settling
5. dry with materialdried over magnesium sulphate
6. customevaporated
7. customThe residue obtained
8. customis purified by chromatography on a column of silica
9. washeluted with heptane