反应详情

18.31 g (100.0 mmol) of 2,5-dichloro-2,5-dimethylhexane, 17.10 g (100.0 mmol) of 2-bromotoluene and 200 ml of 1,2-dichloroethane are introduced into a three-necked flask under an argon atmosphere. 1.33 g (10.0 mmol) of aluminium chloride are added rapidly in a single portion and the reaction medium is stirred for thirty minutes at room temperature. The reaction medium is poured into water, extracted with dichloromethane and washed with water, and the organic phase is separated out after settling has taken place, dried over magnesium sulphate and evaporated. After recrystallization of the residue from methanol, 17.78 g (63%) of the expected compound are collected in the form of fine white crystals with a melting point of 73° C.

1. extractionextracted with dichloromethane
2. washwashed with water
3. customthe organic phase is separated out after settling
4. dry with materialdried over magnesium sulphate
5. customevaporated
6. customAfter recrystallization of the residue from methanol, 17.78 g (63%) of the expected compound
7. customare collected in the form of fine white crystals with a melting point of 73° C.