HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isonicotinic Acid → HCID 178473973, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isonicotinic Acid | HCID 5922 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 1-Acetyl-6-chloro-1,3-dihydro-2H-indol-2-one | HCID 11644161 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178473973 | HCID 178473973 | — |
Reaction Steps
6.3 g of 1-acetyl-6-chloro-2-indolinone, 4.06 g pyridine-4-carboxylic acid, 10.6 g TBTU and 21 ml triethylamine are stirred in 60 ml of DMF for 15 hours at ambient temperature. The mixture is combined with water, then adjusted to pH 5 by the addition of 10% acetic acid. The precipitate is suction filtered, washed with water and taken up in ethyl acetate. The solution obtained is dried with sodium sulphate and evaporated almost to dryness. The precipitate obtained is suction filtered and dried at 100° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07148249B2 |
| Source dataset | uspto-grants-2006_12 |
| ORD ID | ord-5a3491756720439c9500648334c12073 |
| Source note | uspto-grants-2006_12 |