反应详情

6.3 g of 1-acetyl-6-chloro-2-indolinone, 4.06 g pyridine-4-carboxylic acid, 10.6 g TBTU and 21 ml triethylamine are stirred in 60 ml of DMF for 15 hours at ambient temperature. The mixture is combined with water, then adjusted to pH 5 by the addition of 10% acetic acid. The precipitate is suction filtered, washed with water and taken up in ethyl acetate. The solution obtained is dried with sodium sulphate and evaporated almost to dryness. The precipitate obtained is suction filtered and dried at 100° C.

1. filtrationfiltered
2. washwashed with water
3. customThe solution obtained
4. dry with materialis dried with sodium sulphate
5. customevaporated almost to dryness
6. customThe precipitate obtained
7. filtrationfiltered
8. customdried at 100° C.