Hydrochloric Acid → HCID 178480830, compound

HRID 858310Notes

Reaction equation

HRID 858310 reaction equation
C[O:2][C:3]([C:5]1[CH:13]=[C:12]2[C:8](/[C:9](=[C:15](/[NH:26][C:27]3[CH:32]=[CH:31][C:30]([CH2:33][N:34]4[CH2:39][CH2:38][N:37]([CH3:40])[CH2:36][CH2:35]4)=[CH:29][CH:28]=3)\[C:16]3[CH:21]=[CH:20][C:19]4[O:22][CH2:23][CH2:24][O:25][C:18]=4[CH:17]=3)/[C:10](=[O:14])[NH:11]2)=[CH:7][CH:6]=1)=[O:4].[OH-].[Na+].Cl.O>C(O)C>[C:3]([C:5]1[CH:13]=[C:12]2[C:8](/[C:9](=[C:15](/[NH:26][C:27]3[CH:32]=[CH:31][C:30]([CH2:33][N:34]4[CH2:35][CH2:36][N:37]([CH3:40])[CH2:38][CH2:39]4)=[CH:29][CH:28]=3)\[C:16]3[CH:21]=[CH:20][C:19]4[O:22][CH2:23][CH2:24][O:25][C:18]=4[CH:17]=3)/[C:10](=[O:14])[NH:11]2)=[CH:7][CH:6]=1)([OH:4])=[O:2]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 178497144HCID 178497144, compound

Product 1

HCID 178480830HCID 178480830, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

0.36 g of 6-methoxycarbonyl-3-(Z)-{1-[4-(1-methylpiperazin-4-yl-methyl)-phenylamino]-1-(3,4-ethylenedioxyphenyl)-methylene}-2-indolinone (Example 1.57) in 5 ml of ethanol are combined at 80° C. with 1.6 ml of 1 molar sodium hydroxide solution and stirred for 2 hours at 80° C. After the addition of 1.6 ml of 1 molar hydrochloric acid and 2 ml of water the mixture is stirred overnight without any heating. The precipitate formed is suction filtered, washed successively with water, a little ethanol and finally diethyl ether and then dried at 80° C.

Workup

  1. stirringis stirred overnight without any heating
  2. customThe precipitate formed
  3. filtrationfiltered
  4. washwashed successively with water
  5. dry with materiala little ethanol and finally diethyl ether and then dried at 80° C.

Sources & evidence

ORD record
ord-d095a7f40686468e8d53feafb516912b
Source dataset
uspto-grants-2006_12
Patent number
US07148249B2

Reaction notes

Loading…