反应详情

To a solution of methyl 2-(2-chloro-4-nitrophenyl)acetate (step 3, 3.6 g, 15.6 mmol) in ethanol/water (4/1) were added Fe (4.4 g, 78.0 mmol) and NH4Cl (409 mg, 7.8 mmol). The mixture was stirred for 1 h under reflux temperature. The solvent was removed and the residue was diluted with CH2Cl2. The mixture was washed with brine, dried (MgSO4) and concentrated to give 2.59 g (83%) of title compound as orange oil.

1. temperatureunder reflux temperature
2. customThe solvent was removed
3. additionthe residue was diluted with CH2Cl2
4. washThe mixture was washed with brine
5. dry with materialdried (MgSO4)
6. concentrationconcentrated