Acetic Anhydride → HCID 21876062, compound

HRID 858519Notes

Reaction equation

HRID 858519 reaction equation
[NH2:1][C:2]1[N:12]([C:13]2[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][NH:21][C:22]([NH:24][S:25]([C:28]3[CH:33]=[CH:32][C:31]([CH3:34])=[CH:30][CH:29]=3)(=[O:27])=[O:26])=[O:23])=[CH:15][CH:14]=2)[C:5]2=[N:6][C:7]([CH3:11])=[CH:8][C:9]([CH3:10])=[C:4]2[N:3]=1.[CH3:35][C:36](OC(C)=O)=[O:37]>N1C=CC=CC=1>[CH3:11][C:7]1[N:6]=[C:5]2[N:12]([C:13]3[CH:14]=[CH:15][C:16]([CH2:19][CH2:20][NH:21][C:22]([NH:24][S:25]([C:28]4[CH:33]=[CH:32][C:31]([CH3:34])=[CH:30][CH:29]=4)(=[O:27])=[O:26])=[O:23])=[CH:17][CH:18]=3)[C:2]([NH:1][C:36](=[O:37])[CH3:35])=[N:3][C:4]2=[C:9]([CH3:10])[CH:8]=1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 218758602-amino-5,7-dimethyl-3-(4-{2-[({[(4-methylphenyl)sulfonyl]amino}carbonyl)amino]ethyl}phenyl)-3H-imidazo[4,5-b]pyridine

Product 1

HCID 21876062HCID 21876062, compoundYield 5%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

2-amino-5,7-dimethyl-3-(4-{2-[({[(4-methylphenyl)sulfonyl]amino}carbonyl)amino]ethyl}phenyl)-3H-imidazo[4,5-b]pyridine (73 mg) was treated with pyridine (1 ml) and Ac2O (0.2 ml) at room temperature for 3 hours. After evaporation in vacuo, the residue was purified by preparative TLC (hexane/acetone=1/1) to afford 4 mg (5%) of the title compounds.

Workup

  1. customAfter evaporation in vacuo
  2. customthe residue was purified by preparative TLC (hexane/acetone=1/1)

Sources & evidence

ORD record
ord-fdc420d50e054299af1a023a00786dec
Source dataset
uspto-grants-2006_12
Patent number
US07148234B2

Reaction notes

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