反应详情

Acetic anhydride (0.51 mL, 5.4 mmol) and triethylamine (0.75 mL, 5.4 mmol) were added to a solution of 3,5-dimethyl-4-iodopyrazole (1 g, 4.5 mmol) in CH2Cl2. After 1 h the reaction mixture was partitioned between 1 N HCl and EtOAc. The organic layer was washed with 1 N HCl, saturated NaHCO3, brine, dried over Na2SO4, and concentrated to give the title compound as a white solid (1 g, 85%).

1. customAfter 1 h the reaction mixture was partitioned between 1 N HCl and EtOAc
2. washThe organic layer was washed with 1 N HCl, saturated NaHCO3, brine
3. dry with materialdried over Na2SO4
4. concentrationconcentrated