Trifluoroacetic acid → HCID 68866292, compound

Participants

Reaction Steps

A solution of (4-Bromo-3-fluoro-phenyl)-thiazol-2-yl-methanol (3.4 g, 12.6 mmol), TFA (25 mL), and Triethylsilane (10 mL, 63 mmol), were refluxed overnight. The reaction was then concentrated under vacuum, and purified by silica gel chromatography (gradient elution 10–40% Ethylacetate/Hexanes). Yield 1.96 g, 61%.

Provenance & Evidence