Trifluoroacetic acid → HCID 68866292, compound

HRID 858596Notes

Reaction equation

HRID 858596 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:10]2[S:11][CH:12]=[CH:13][N:14]=2)O)=[CH:4][C:3]=1[F:15].C(O)(C(F)(F)F)=O.C([SiH](CC)CC)C>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:10]2[S:11][CH:12]=[CH:13][N:14]=2)=[CH:4][C:3]=1[F:15]

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 12052TriethylsilaneHCID 68868665HCID 68868665, compound

Product 1

HCID 68866292HCID 68866292, compound

Procedure

A solution of (4-Bromo-3-fluoro-phenyl)-thiazol-2-yl-methanol (3.4 g, 12.6 mmol), TFA (25 mL), and Triethylsilane (10 mL, 63 mmol), were refluxed overnight. The reaction was then concentrated under vacuum, and purified by silica gel chromatography (gradient elution 10–40% Ethylacetate/Hexanes). Yield 1.96 g, 61%.

Workup

  1. concentrationThe reaction was then concentrated under vacuum
  2. custompurified by silica gel chromatography (gradient elution 10–40% Ethylacetate/Hexanes)

Sources & evidence

ORD record
ord-d9c476169c4844aca0df6e5ee2308dd6
Source dataset
uspto-grants-2006_12
Patent number
US07148226B2

Reaction notes

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