反应详情

400 mg (0.68 mmol) of 3-[4,6-dichloro-5-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-2-pyrimidinyl]-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine (example XII, step 7) are dissolved in 200 ml of methanol, and 86 mg of ammonium formate are added. Under argon, 26 mg of palladium on activated carbon (10%) are added, and the mixture is heated under reflux for 3 days. The reaction mixture is filtered and the residues are washed with methanol. The solvent is removed in vacuo, and the residue is purified by preparative HPLC. 99 mg (35% of theory) of the product are obtained.

1. temperaturethe mixture is heated
2. temperatureunder reflux for 3 days
3. filtrationThe reaction mixture is filtered
4. washthe residues are washed with methanol
5. customThe solvent is removed in vacuo
6. customthe residue is purified by preparative HPLC
7. custom99 mg (35% of theory) of the product are obtained