HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Bromo-2-fluorophenyl)cyclopropane-1-carbonitrile → 2-(4-Bromo-2-fluoro-5-methoxy-phenyl)-2-methyl-propionitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Bromo-2-fluorophenyl)cyclopropane-1-carbonitrile | HCID 58762329 | — |
| Reactant | 2-{4-[2-(2-Cyclopentyl-4-hydroxy-6-oxo-3,6-dihydro-2H-pyran-2-yl)-ethyl]-2-fluoro-5-methoxy-phenyl}-2-methyl-propionitrile | HCID 68865262 | — |
| Product | 2-(4-Bromo-2-fluoro-5-methoxy-phenyl)-2-methyl-propionitrile | HCID 68868796 | — |
Reaction Steps
The desired product was prepared analogously to Example A (97) step 2, substituting (4-Bromo-2-fluoro-5-methoxy-phenyl)-acetonitrile (1.95 g, 8.0 mmol) from step 4 below in place of 1-(4-bromo-2-fluoro-phenyl)-cyclopropanecarbonitrile. Yield: 8.72 g, 96.0%. 1H NMR (CDCl3) δ: 1.34 (s, 6H), 3.92 (s, 3H), 7.06 (d, J=6.8 Hz, 1H), 7.33 (d, J=10.6 Hz, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07148226B2 |
| Source dataset | uspto-grants-2006_12 |
| ORD ID | ord-8d79a709bd0d4867a97e41cef8e4d3f1 |
| Source note | uspto-grants-2006_12 |