6-[2-(5-Chloro-2,4-dimethoxy-phenyl)ethyl]-6-cyclopentyl-tetrahydropyran-2,4-dione → HCID 136152588, compound

HRID 858744Notes

Reaction equation

HRID 858744 reaction equation
Cl[CH2:2][C:3]1[NH:12][C:11](=[O:13])[C:10]2[C:5](=[CH:6][C:7]([O:16][CH3:17])=[C:8]([O:14][CH3:15])[CH:9]=2)[N:4]=1.[Cl:18][C:19]1[C:20]([O:42][CH3:43])=[CH:21][C:22]([O:40][CH3:41])=[C:23]([CH2:25][CH2:26][C:27]2([CH:35]3[CH2:39][CH2:38][CH2:37][CH2:36]3)[O:32][C:31](=[O:33])[CH2:30][C:29](=[O:34])[CH2:28]2)[CH:24]=1>>[Cl:18][C:19]1[C:20]([O:42][CH3:43])=[CH:21][C:22]([O:40][CH3:41])=[C:23]([CH2:25][CH2:26][C:27]2([CH:35]3[CH2:39][CH2:38][CH2:37][CH2:36]3)[O:32][C:31](=[O:33])[C:30]([CH2:2][C:3]3[NH:12][C:11](=[O:13])[C:10]4[C:5](=[CH:6][C:7]([O:16][CH3:17])=[C:8]([O:14][CH3:15])[CH:9]=4)[N:4]=3)=[C:29]([OH:34])[CH2:28]2)[CH:24]=1

Participants

3

Reactant 2

HCID 167287016-[2-(5-Chloro-2,4-dimethoxy-phenyl)ethyl]-6-cyclopentyl-tetrahydropyran-2,4-dioneHCID 1354735692-(chloromethyl)-6,7-dimethoxyquinazolin-4(3H)-one

Product 1

HCID 136152588HCID 136152588, compoundYield 20%

Procedure

The title compound was prepared as described in Example B(53), using 2-(chloromethyl)-6,7-dimethoxyquinazolin-4(3H)-one (Example B(57), Step 1) in place of 5-(chloromethyl)-1,3-dimethyl-1H-1,2,4-triazole, and using 6-[2-(5-chloro-2,4-dimethoxyphenyl)ethyl]-6-cyclopentyldihydro-2H-pyran-2,4(3H)-dione in place of 6-[2-(3-chloro-4-methoxyphenyl)ethyl]-6-cyclopentyldihydro-2H-pyran-2,4(3H)-dione. Yield: 20%.

Sources & evidence

ORD record
ord-f70a489fc3ed4e869fac1aab095dcf44
Source dataset
uspto-grants-2006_12
Patent number
US07148226B2

Reaction notes

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