Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-Chloro-6-(2-cyclohex-1-enyl-ethyl)6-cyclopentyl-4-hydroxy-5,6-dihydro-pyran-2-one | HCID 57527269 | — |
| Reactant | 5-pyridin-4-yl-1H-1,2,4-triazole-3-thiol | HCID 178527960 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178519101 | HCID 178519101 | 27% |
Reaction Steps
A solution of 3-Chloro-6-(2-cyclohex-1-enyl-ethyl)-6-cyclopentyl-4-hydroxy-5,6-dihydro-pyran-2-one (150 mg, 0.46 mmol, from Step 1 below), 5-Pyridin-4-yl-4H-[1,2,4]triazole-3-thiol (82 mg, 0.46 mmol), and triethylamine (64 □L, 0.46 mmol) dissolved in DMF (5 mL) was heated to 55° C. under N2 for 8 h. The resulting mixture was concentrated and purified by Prep HPLC to give the title compound (58 mg, 27%) as a pale yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07148226B2 |
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| Source dataset | uspto-grants-2006_12 |
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| ORD ID | ord-f285b83780054a808b00b28bf142e322 |
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| Source note | uspto-grants-2006_12 |
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