Potassium Carbonate → HCID 10369461, compound

HRID 859016Notes

Reaction equation

HRID 859016 reaction equation
[C:1]1([CH:7]([O:37]C(=O)C)[C:8](=[O:36])[NH:9][C:10]2[S:11][C:12]3[CH:18]=[CH:17][CH:16]=[C:15]([O:19][C:20]4[CH:25]=[C:24]([C:26]5[CH:31]=[CH:30][C:29]([C:32]([F:35])([F:34])[F:33])=[CH:28][CH:27]=5)[N:23]=[CH:22][N:21]=4)[C:13]=3[N:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(=O)([O-])[O-].[K+].[K+]>CO>[OH:37][CH:7]([C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[C:8]([NH:9][C:10]1[S:11][C:12]2[CH:18]=[CH:17][CH:16]=[C:15]([O:19][C:20]3[CH:25]=[C:24]([C:26]4[CH:27]=[CH:28][C:29]([C:32]([F:33])([F:34])[F:35])=[CH:30][CH:31]=4)[N:23]=[CH:22][N:21]=3)[C:13]=2[N:14]=1)=[O:36]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 58759724HCID 58759724, compound

Product 1

HCID 10369461HCID 10369461, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

This material was prepared according to the procedure described in Example 68(b) using acetic acid phenyl-{4-[6-(4-trifluoromethyl-phenyl)-pyrimidin-4-yloxy]-benzothiazol-2-ylcarbamoyl}-methyl ester, (Example 79), (0.44 g, 0.78 mmol) and potassium carbonate (0.22 g, 1.6 mmol) in MeOH (8 mL). Purification by silica gel chromatography (1:2 of EtOAc/hexanes) provided the title compound as a white solid. MS (ESI, pos. ion) m/z: 523 (M+1). Mp: 197.7–205.4° C.

Workup

  1. customThis material was prepared
  2. customPurification by silica gel chromatography (1:2 of EtOAc/hexanes)

Sources & evidence

ORD record
ord-ff9990e609e045a58c6ea3541d9994fa
Source dataset
uspto-grants-2006_12
Patent number
US07148221B2

Reaction notes

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