反应详情

温度

110 °C

A mixture of N-[3-carboxy-phenyl]-4-(2-chloro-4-pyridyl)-2-pyrimidineamine (99 mg, 0.30 mmol) in 1,4-diaminobutane (1.5 mL) is heated to 110° C. overnight, cooled to room temperature and concentrated. The residue is dissolved in water and neutralized with 10% hydrochloric acid. The reaction mixture is purified by preparative HPLC to give N-[3-carboxy-phenyl]-4-[2-(4-amino-butyl-amino)-4-pyridyl]-2-pyrimidineamine (84 mg); ESI-MS (m/z): 379 (M++H).

1. temperaturecooled to room temperature
2. concentrationconcentrated
3. dissolutionThe residue is dissolved in water and neutralized with 10% hydrochloric acid
4. customThe reaction mixture is purified by preparative HPLC