HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 859105Generated: November 2, 2026
N-[3-carboxy-phenyl]-4-(2-chloro-4-pyridyl)-2-pyrimidineamine → N-[3-carboxy-phenyl]-4-[2-(4-amino-butyl-amino)-4-pyridyl]-2-pyrimidineamine
https://huagongshe.com/reaction/859105
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N-[3-carboxy-phenyl]-4-(2-chloro-4-pyridyl)-2-pyrimidineamine | HCID 19689614 | — |
| Solvent | Putrescine | HCID 1045 | — |
| Product | N-[3-carboxy-phenyl]-4-[2-(4-amino-butyl-amino)-4-pyridyl]-2-pyrimidineamine | HCID 69630624 | 148% |
Reaction Steps
A mixture of N-[3-carboxy-phenyl]-4-(2-chloro-4-pyridyl)-2-pyrimidineamine (99 mg, 0.30 mmol) in 1,4-diaminobutane (1.5 mL) is heated to 110° C. overnight, cooled to room temperature and concentrated. The residue is dissolved in water and neutralized with 10% hydrochloric acid. The reaction mixture is purified by preparative HPLC to give N-[3-carboxy-phenyl]-4-[2-(4-amino-butyl-amino)-4-pyridyl]-2-pyrimidineamine (84 mg); ESI-MS (m/z): 379 (M++H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07151096B2 |
|---|
| Source dataset | uspto-grants-2006_12 |
|---|
| ORD ID | ord-119f9f38da2a41d3a171c7d28e831c10 |
|---|
| Source note | uspto-grants-2006_12 |
|---|
