反应详情

温度

5 °C

A mixture of 5 g (0.026 mole) of 3-chlorobiphenyl, 50 ml of methylene chloride, 6.95 g (0.034 mole) of bromoacetyl bromide is cooled to 0–5° C. and 4 g (0.030 mole) of aluminum trichloride are added. The mixture is stirred for 1 hour at 5° C., then for 4 hours at room temperature. It is poured onto an ice/water mixture, extracted with methylene chloride, the organic phase is washed with a 1N solution of HCl, dried over sodium sulfate and evaporated under reduced pressure. 4.5 g of the title product is obtained. M.p. 63–65° C.

1. temperatureis cooled to 0–5° C.
2. waitfor 4 hours at room temperature
3. extractionextracted with methylene chloride
4. washthe organic phase is washed with a 1N solution of HCl
5. dry with materialdried over sodium sulfate
6. customevaporated under reduced pressure