HCID 23063806, compound → 3-(5-Hydroxy-1H-indol-3-yl)-1H-pyrrole-2,5-dione

HRID 859125Notes

Reaction equation

HRID 859125 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:15][C:14](=[O:16])[NH:13][C:12]1=[O:17]>CO>[OH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[C:11]1[C:12](=[O:17])[NH:13][C:14](=[O:16])[CH:15]=1

Participants

3

Reactant 1

HCID 23063806HCID 23063806, compound

Product 1

HCID 216558433-(5-Hydroxy-1H-indol-3-yl)-1H-pyrrole-2,5-dione

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3-(5-hydroxy-1H-indol-3-yl)-2,5-pyrrolidinedione 10% palladium-on-carbon (135 mg) is added to a solution of the compound of Step A of Preparation H (450 mg) in dry methanol (90 ml). After having purged in vacuo for 20 minutes, the reaction mixture is placed under a hydrogen atmosphere (1 atm) for 3 hours. Following filtration over Celite and evaporation of the filtrate, the expected product is obtained.

Workup

  1. customAfter having purged in vacuo for 20 minutes
  2. customfor 3 hours
  3. filtrationfiltration
  4. customover Celite and evaporation of the filtrate

Sources & evidence

ORD record
ord-5ed9bd6f1fc641e49664c5f0ba3e2c5a
Source dataset
uspto-grants-2006_12
Patent number
US07151108B2

Reaction notes

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