Ethanol hydrochloride → HCID 58763949, compound

HRID 859193Notes

Reaction equation

C(OC([NH:8][CH2:9][CH2:10][NH:11][C:12]1[C:13]([C:31]([OH:33])=[O:32])=[N:14][N:15]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[Cl:30])[C:16]=1[C:17]1[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=1)=O)(C)(C)C.Cl.CCO>>[NH2:8][CH2:9][CH2:10][NH:11][C:12]1[C:13]([C:31]([OH:33])=[O:32])=[N:14][N:15]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[Cl:30])[C:16]=1[C:17]1[CH:18]=[CH:19][C:20]([Cl:23])=[CH:21][CH:22]=1

Participants

Reactant 2

HCID 21887872Ethanol hydrochloride

HCID 58763940HCID 58763940, compound

Product 1

HCID 58763949HCID 58763949, compound

Procedure

A solution of 4-(2-tert-butoxycarbonylaminoethylamino)-1-(2-chlorophenyl)-5-(4-chlorophenyl)-1H-pyrazole-3-carboxylic acid (I-4c, 879 mg) in 2:1 conc HCl/EtOH (12 ml) was allowed to stand at room temperature for 17 hours. The reaction mixture was concentrated under vacuum to give the desired product I-4d: +ES MS (M+1) 391.4.

Workup

concentrationThe reaction mixture was concentrated under vacuum

Sources & evidence

ORD record: ord-1334e5a173024bda8cccfca22638ab2d
Source dataset: uspto-grants-2006_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07151097B2

Reaction notes

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