反应详情

温度

50 °C

A solution of 25.61 g (74.6 mmol) of (S)-1-[4-(3-fluoro-benzyloxy)-phenyl]-5-oxo-pyrrolidine-3-carboxylic acid methyl ester in 650 ml of dioxane is treated with 175 ml of hydrochloric acid (37%). The mixture is heated at 50° C. for 18 h in a closed flask. For the working-up, the solution is evaporated under reduced pressure to yield the crude acid as a yellow solid. For purification, the crude acid is triturated at 0° C. in 50 ml of ethyl acetate. The solid is collected on a filter funnel and then dried under high vacuum to yield 20.3 g (82% of theory) of (S)-1-[4-(3-fluoro-benzyloxy)-phenyl]-5-oxo-pyrrolidine-3-carboxylic acid as a yellowish solid; MS: m/e=330 (M+H)+.

1. customthe solution is evaporated under reduced pressure
2. customto yield the crude acid as a yellow solid
3. customFor purification
4. customthe crude acid is triturated at 0° C. in 50 ml of ethyl acetate
5. customThe solid is collected on a filter funnel
6. customdried under high vacuum