Tert-butyl (4-iodo-2-nitrophenyl)carbamate → HCID 69592854, compound

HRID 859264Notes

Reaction equation

HRID 859264 reaction equation
[C:1]([O:5][C:6](=[O:18])[NH:7][C:8]1[CH:13]=[CH:12][C:11](I)=[CH:10][C:9]=1[N+:15]([O-:17])=[O:16])([CH3:4])([CH3:3])[CH3:2].[F:19][C:20]1[CH:25]=[CH:24][C:23](B(O)O)=[C:22]([O:29][CH2:30][O:31][CH3:32])[CH:21]=1>>[C:1]([O:5][C:6](=[O:18])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:23]2[CH:24]=[CH:25][C:20]([F:19])=[CH:21][C:22]=2[O:29][CH2:30][O:31][CH3:32])=[CH:10][C:9]=1[N+:15]([O-:17])=[O:16])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 23554339Tert-butyl (4-iodo-2-nitrophenyl)carbamateHCID 69592844HCID 69592844, compound

Product 1

HCID 69592854HCID 69592854, compound

Procedure

Prepared from (4-iodo-2-nitro-phenyl)-carbamic acid tert.-butyl ester (Example A1) and 4-fluoro-2-methoxymethoxybenzene boronic acid [prepared from 1-bromo-4-fluoro-2-(methoxymethoxy)benzene (CAS-no. 162269-78-5) by reaction with n-BuLi at −78° C. followed by treatment with B(OMe)3 and subsequent hydrolysis] according to the general procedure B. Obtained as a yellow solid (0.96 g).

Sources & evidence

ORD record
ord-a8651c8ce30645c99ab6a7e774d1848b
Source dataset
uspto-grants-2006_12
Patent number
US07151098B2

Reaction notes

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