Stannous chloride dihydrate → (2-Amino-4-cyclopropyl-phenyl)-carbamic acid tert-butyl ester

HRID 859342Notes

Reaction equation

HRID 859342 reaction equation
[C:1]([O:5][C:6](=[O:20])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([CH:14]2[CH2:16][CH2:15]2)=[CH:10][C:9]=1[N+:17]([O-])=O)([CH3:4])([CH3:3])[CH3:2].O.O.Cl[Sn]Cl>>[C:1]([O:5][C:6](=[O:20])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([CH:14]2[CH2:16][CH2:15]2)=[CH:10][C:9]=1[NH2:17])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 61436Stannous chloride dihydrateHCID 69592793(4-Cyclopropyl-2-nitro-phenyl)-carbamic acid tert.-butyl ester

Product 1

HCID 69592759(2-Amino-4-cyclopropyl-phenyl)-carbamic acid tert-butyl ester

Procedure

Prepared from (4-cyclopropyl-2-nitro-phenyl)-carbamic acid tert.-butyl ester (Example A3) by reduction with SnCl2.2H2O according to the general procedure G (method b). Obtained as a dark solid (1.96 g).

Sources & evidence

ORD record
ord-d195ab531423472c889953f5f95291e9
Source dataset
uspto-grants-2006_12
Patent number
US07151098B2

Reaction notes

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