(2-Amino-4-phenylethynyl-phenyl)-carbamic acid tert-butyl ester → HCID 86587994, compound

HRID 859387Notes

Reaction equation

HRID 859387 reaction equation
[C:1]([O:5][C:6](=[O:23])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]#[C:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:10][C:9]=1[NH2:22])([CH3:4])([CH3:3])[CH3:2].[I:24][C:25]1[CH:26]=[C:27]([C:31]2[O:36]C(C)(C)[O:34][C:33](=O)[CH:32]=2)[CH:28]=[CH:29][CH:30]=1>>[C:1]([O:5][C:6](=[O:23])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]#[C:15][C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)=[CH:10][C:9]=1[NH:22][C:33](=[O:34])[CH2:32][C:31]([C:27]1[CH:28]=[CH:29][CH:30]=[C:25]([I:24])[CH:26]=1)=[O:36])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 11404065(2-Amino-4-phenylethynyl-phenyl)-carbamic acid tert-butyl esterHCID 22224697HCID 22224697, compound

Product 1

HCID 86587994HCID 86587994, compoundYield 101%

Procedure

Prepared from (2-amino-4-phenylethynyl-phenyl)-carbamic acid tert.-butyl ester (Example G2) (1.0 g, 3.24 mmol) and 6-(3-iodo-phenyl)-2,2-dimethyl-[1,3]dioxin-4-one (Example J7) (1.78 g, 3.57 mmol) according to the general procedure K. Obtained as a light yellow solid (1.9 g).

Sources & evidence

ORD record
ord-f7f19ddd0d0e42769addb7dc0bb02a42
Source dataset
uspto-grants-2006_12
Patent number
US07151098B2

Reaction notes

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