6-(3-Chloro-thiophen-2-yl)-2,2-dimethyl-[1,3]dioxin-4-one → {3-[3-(3-Chloro-thiophen-2-yl)-3-oxo-propionylamino]-2'-methyl-biphenyl-4-yl}-carbamic acid tert.-butyl ester

HRID 859397Notes

Reaction equation

HRID 859397 reaction equation
[C:1]([O:5][C:6](=[O:22])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[CH3:20])=[CH:10][C:9]=1[NH2:21])([CH3:4])([CH3:3])[CH3:2].[Cl:23][C:24]1[CH:28]=[CH:27][S:26][C:25]=1[C:29]1[O:34]C(C)(C)[O:32][C:31](=O)[CH:30]=1>>[C:1]([O:5][C:6](=[O:22])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[CH3:20])=[CH:10][C:9]=1[NH:21][C:31](=[O:32])[CH2:30][C:29]([C:25]1[S:26][CH:27]=[CH:28][C:24]=1[Cl:23])=[O:34])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 222247756-(3-Chloro-thiophen-2-yl)-2,2-dimethyl-[1,3]dioxin-4-oneHCID 67288955Carbamic acid,(3-amino-2'-methyl[1,1'-biphenyl]-4-yl)-,1,1-dimethylethyl ester

Product 1

HCID 86588005{3-[3-(3-Chloro-thiophen-2-yl)-3-oxo-propionylamino]-2'-methyl-biphenyl-4-yl}-carbamic acid tert.-butyl ester

Procedure

Prepared from (3-amino-2′-methyl-biphenyl-4-yl)-carbamic acid tert.-butyl ester (Example G23) and 6-(3-chloro-thiophen-2-yl)-2,2-dimethyl-[1,3]dioxin-4-one (Example J2) according to the general procedure K. Obtained as a viscous brown oil (154 mg).

Sources & evidence

ORD record
ord-a951859665d04f89a250ac2b989df0e4
Source dataset
uspto-grants-2006_12
Patent number
US07151098B2

Reaction notes

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