6-(3-Chloro-thiophen-2-yl)-2,2-dimethyl-[1,3]dioxin-4-one → {3-[3-(3-Chloro-thiophen-2-yl)-3-oxo-propionylamino]-2'-methyl-biphenyl-4-yl}-carbamic acid tert.-butyl ester

Participants

Role	Name	HCID	Charge
Reactant	6-(3-Chloro-thiophen-2-yl)-2,2-dimethyl-[1,3]dioxin-4-one	HCID 22224775	—
Reactant	Carbamic acid,(3-amino-2'-methyl[1,1'-biphenyl]-4-yl)-,1,1-dimethylethyl ester	HCID 67288955	—
Product	{3-[3-(3-Chloro-thiophen-2-yl)-3-oxo-propionylamino]-2'-methyl-biphenyl-4-yl}-carbamic acid tert.-butyl ester	HCID 86588005	—

Reaction Steps

Prepared from (3-amino-2′-methyl-biphenyl-4-yl)-carbamic acid tert.-butyl ester (Example G23) and 6-(3-chloro-thiophen-2-yl)-2,2-dimethyl-[1,3]dioxin-4-one (Example J2) according to the general procedure K. Obtained as a viscous brown oil (154 mg).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07151098B2
Source dataset	uspto-grants-2006_12
ORD ID	ord-a951859665d04f89a250ac2b989df0e4
Source note	uspto-grants-2006_12