(2-Amino-4-phenylethynyl-phenyl)-carbamic acid tert-butyl ester → HCID 86588015, compound

HRID 859407Notes

Reaction equation

HRID 859407 reaction equation
[C:1]([O:5][C:6](=[O:23])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]#[C:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:10][C:9]=1[NH2:22])([CH3:4])([CH3:3])[CH3:2].[N:24]1([C:29]2[CH:30]=[C:31]([C:35]3[O:40]C(C)(C)[O:38][C:37](=O)[CH:36]=3)[CH:32]=[CH:33][CH:34]=2)[CH:28]=[CH:27][N:26]=[CH:25]1>>[C:1]([O:5][C:6](=[O:23])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]#[C:15][C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)=[CH:10][C:9]=1[NH:22][C:37](=[O:38])[CH2:36][C:35]([C:31]1[CH:32]=[CH:33][CH:34]=[C:29]([N:24]2[CH:28]=[CH:27][N:26]=[CH:25]2)[CH:30]=1)=[O:40])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 11404065(2-Amino-4-phenylethynyl-phenyl)-carbamic acid tert-butyl esterHCID 222248956-(3-Imidazol-1-yl-phenyl)-2,2-dimethyl-[1,3]dioxin-4-one

Product 1

HCID 86588015HCID 86588015, compoundYield 68.8%

Procedure

Prepared from (2-amino-4-phenylethynyl-phenyl)-carbamic acid tert.-butyl ester (Example G2) (154 mg, 0.5 mmol) and 6-(3-imidazol-1-yl-phenyl)-2,2-dimethyl-[1,3]dioxin-4-one (Example J10) (135 mg, 0.5 mmol) according to the general procedure K. Obtained as an orange oil (179 mg).

Sources & evidence

ORD record
ord-936cb189b8294fe4b84070ad074d221b
Source dataset
uspto-grants-2006_12
Patent number
US07151098B2

Reaction notes

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