Trifluoroacetic acid → 4-(3-Imidazol-1-yl-phenyl)-8-phenyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one

HRID 859522Notes

Reaction equation

HRID 859522 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11](C2C=CC=CC=2)=[CH:10][C:9]=1[NH:20][C:21](=O)[CH2:22][C:23]([C:25]1C=C[CH:28]=[C:27]([N:31]2[CH:35]=[CH:34][N:33]=[CH:32]2)[CH:26]=1)=O)(C)(C)C.[C:38](O)([C:40](F)(F)F)=[O:39]>C(Cl)Cl>[N:31]1([C:27]2[CH:28]=[C:22]([C:21]3[CH2:40][C:38](=[O:39])[NH:7][C:8]4[CH:13]=[C:12]([C:8]5[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=5)[CH:11]=[CH:10][C:9]=4[N:20]=3)[CH:23]=[CH:25][CH:26]=2)[CH:35]=[CH:34][N:33]=[CH:32]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86588021{3-[3-(3-Imidazol-1-yl-phenyl)-3-oxo-propionylamino]-biphenyl-4-yl}-carbamic acid tert.-butyl ester

Product 1

HCID 222245704-(3-Imidazol-1-yl-phenyl)-8-phenyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared from {3-[3-(3-imidazol-1-yl-phenyl)-3-oxo-propionylamino]-biphenyl-4-yl}-carbamic acid tert.-butyl ester (Example K34) by treatment with TFA in CH2Cl2 according to the general procedure M. Obtained as a light yellow solid (125 mg).

Sources & evidence

ORD record
ord-9e36bb15c93142c59b4b7e7d28e410bb
Source dataset
uspto-grants-2006_12
Patent number
US07151098B2

Reaction notes

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