Trifluoroacetic acid → HCID 22224851, compound

HRID 859546Notes

Reaction equation

HRID 859546 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2C=C[CH:17]=[CH:16][C:15]=2F)=[CH:10][C:9]=1[NH:21][C:22](=[O:34])[CH2:23][C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([C:32]#[N:33])[CH:27]=1)=O)(C)(C)C.[C:36](O)([C:38]([F:41])(F)F)=O>C(Cl)Cl>[F:41][C:38]1[CH:36]=[CH:17][CH:16]=[CH:15][C:14]=1[C:11]1[CH:12]=[CH:13][C:8]2[N:7]=[C:24]([C:26]3[CH:27]=[C:28]([CH:29]=[CH:30][CH:31]=3)[C:32]#[N:33])[CH2:23][C:22](=[O:34])[NH:21][C:9]=2[CH:10]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86588042HCID 86588042, compound

Product 1

HCID 22224851HCID 22224851, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared from {3-[3-(3-cyano-phenyl)-3-oxo-propionylamino]-2′-fluoro-biphenyl-4-yl}-carbamic acid tert.-butyl ester (Example K57) by treatment with TFA in CH2Cl2 according to the general procedure M. Obtained as a light yellow solid (128 mg).

Sources & evidence

ORD record
ord-ff491f7003fa4b43b8751521d277f766
Source dataset
uspto-grants-2006_12
Patent number
US07151098B2

Reaction notes

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